Guangzhou Royal Lee Tumor Hospital is the largest high-end tertiary cancer specialty hospital in South China. The hospital pioneered the super-platform service model for cancer treatment, bringing together top cancer experts from domestic hospitals and equipped with the world's most advanced large-scale equipment such as PET-CT, MRI, and DSA. Recently, the hospital introduced the first Shanghai Yuanshan Medical independently developed and produced High Voltage Steep Pulse Minimally Invasive Therapeutic System in South China, bringing new minimally invasive treatment methods for complex solid tumor patients.
On the morning of July 19, 2022, Professor Liu Haiying, honorary dean of Guangzhou Royal Lee Tumor Hospital and chief expert in oncology surgery, led a team to personally use this "domestic nano-knife" - Ailuoyi steep pulse minimally invasive treatment system. Through intraoperative ultrasound guidance, the team successfully performed a nano-knife surgery for a patient with liver cancer adjacent to the right portal vein.
The patient is male, 48 years old, with a history of hepatitis B for more than 10 years. 4 months ago, he came to the hospital with discomfort in the right upper abdomen, and CT and other imaging data showed that the right lobe of the liver was 44*49*55 mm occupied, considering the possible combination of the right branch of the portal vein carcinoma embolism, and the preliminary diagnosis: hepatocellular carcinoma in the right lobe of the liver invading the right branch of the portal vein (cT3N1M0 stage IIIc), and had undergone two TACE interventions with poor results.
(Preoperative CT imaging data.)
Innovative Therapy - Nanoknife Ablation Therapy
After receiving the patient, Professor Liu Haiying immediately organized a multidisciplinary consultation for the patient. Professor Liu said, "Considering that the patient has a history of hepatitis B for more than 10 years with cirrhosis, the lesion is in a special location, the tumor has invaded the right branch of the portal vein, and surgical resection would result in a loss of a significant amount of liver tissue, making liver function difficult to tolerate and the surgical risk high. The previous two TACE treatments were ineffective, and conventional thermal ablation has a high risk. The latest Nanoknife technology uses instantaneous ultra-high voltage pulses to cause irreversible nanoscale perforation of tumor cell membranes, disrupt the internal stability of cells, cause irreversible apoptosis of tumor cells, and effectively protect important structures such as blood vessels, bile ducts, and nerves. It is currently the best treatment option for this patient." After adequate preoperative preparation, on July 19, 2022, Dean Liu Haiying personally performed an open abdomen Nanoknife treatment for the patient and achieved success.
The surgery officially began at 9 am, and after laparotomy exploration, needle placement was performed under intraoperative ultrasound guidance, and the electrode needles were wrapped around the lesion and connected to the Nanoknife treatment system to begin electric pulse treatment. During the entire treatment process, the electrode needle position was continuously adjusted by observing the real-time changes in the electric pulse parameters. A total of 11 rounds of electric pulse treatment were performed until the tumor was completely covered. The patient's vital signs were stable during the surgery, and there was almost no bleeding. Seven days after the surgery, CT enhanced scanning showed a low-density shadow in the tumor treatment area, indicating that the tumor treatment was very successful.
(Review imaging data 7 days after surgery)
Nanoknife Technology Breakthrough Traditional Ablation Barriers
Director Liu stated after the surgery that the NanoKnife is a breakthrough in tumor treatment technology as a new type of tumor treatment method. It can effectively treat complex tumors that are unresectable or unsuitable for resection (especially liver cancer, pancreatic cancer, etc.) through intraoperative direct visualization or percutaneous puncture treatment. Conventional surgical resection and traditional thermal ablation techniques are not daring to act rashly on tumors located in densely populated areas of ducts and invading important blood vessels or ducts. Any slightest mistake may cause damage to blood vessels or important ducts, leading to massive bleeding or bile duct or pancreatic duct fistula. Compared with traditional ablation methods, the irreversible electric pulse treatment of the NanoKnife breaks these constraints and does not rely on temperature changes in the ablation area to inactivate tumors. For lesions near larger blood vessels, it is not affected by the "heat sink effect" caused by blood flow during the ablation process, and can protect the vascular structure within the treatment area intact. It brings new hope for patients with liver cancer, pancreatic cancer, and other tumors who cannot undergo surgical resection or conventional ablation treatment.
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Liu Haiying Medical Doctor/Chief Physician/Doctoral Supervisor/Overseas Scholar Former Director of Department of Surgery, Director of Department of Gastrointestinal Surgery and Director of Department of Clinical Nutrition, Affiliated Cancer Hospital of Guangzhou Medical University Standing member of the 5th and 6th Colorectal Cancer Committee of China Anti-Cancer Association Vice Chairman of the 1st Colorectal Surgery Committee of Chinese Physicians Association Vice Chairman of the First to Third Colorectal Cancer Committee of Guangdong Anti-Cancer Association Chairman of the Oncology Branch of Guangzhou Medical Association Honorary President of Guangzhou Royal Cancer Hospital, Chief Specialist of Surgical Oncology Winner of the 9th China Physician Award and the 2nd Guangzhou Physician Award; Lingnan Famous Doctor |
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